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EMD Millipore - 05-23-0101-1MG - Angiotensin II, Human - CAS 4474-91-3 - Calbiochem

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Manufacturer: EMD Millipore
Item #: 6280197
Mfr Part Number: 05-23-0101-1MG
MSRP: $53.50
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Angiotensin II, Human^ ( H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH). Lyophilized solid. Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. This listing is for Each Overview Plays an important role in the regulation of blood pressure.

Stimulates the release of aldosterone from the adrenal gland. Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Has strong vasoconstrictive effects. Increases the entry of Ca 2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase.

Also elicits an increase in voltage-dependent delayed rectifier K + current in neurons. Activates JAK2 in smooth muscle cells. Activates p125 FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates p60 c- src as well as ERK1/2, JNK, and p38 MAP Kinase in vascular smooth muscle cells.

Brand Family Calbiochem Synonyms DRVYIHPF References Zhu, M., et al. 2000. J. Neurophysiol. 84, 2494. Natarajan, R., et al. 1999. Hypertension 33, 378. Mazzolai, L., et al. 1998. Hypertension 31, 1324. Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440. Ishida, M., et al. 1995.

Circ. Res. 77, 1053. Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768. CAS number 4474-91-3 ATP Competitive N Form White to off-white solid Hill Formula CHNO Chemical formula CHNO Hygroscopic Hygroscopic Reversible N Sold on the basis of peptide content Y Primary Target adenylate cyclase activity Purity 98% by HPLC Cell permeable N Peptide Content Y Peptide Sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH RTECS BW2165000 Ship Code Ambient Temperature Only Toxicity Standard Handling Storage -20 C Hygroscopic Hygroscopic Do not freeze Ok to freeze Special Instructions Following reconstitution, aliquot and freeze (-20 C).

Stock solutions are stable for up to 1 week at 4 C or for up to 1 month at -20 C..



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